Department of Defense.ĭedicated to providing comprehensive operative and non-operative treatments for spinal ailmentsDr. His interests extend into strategic planning and entrepreneurship as he is Advisor to Twisted Sun Innovations, a Hygrogen energy company currently working on renewable energy solutions for the U.S. His dedication to advancing spine surgery has also earned him consulting agreements in the spine industry and beyond. ![]() He has acted as an oral examiner and submitted questions for the written exam on its behalf. Kube holds a seat on the Board of Directors for the American Board of Spine Surgery and is currently Treasurer. Kube has maintained an active role in the spine specialty societies and serves or has served on various committees within the North American Spine Society and International Society for the Advancement of Spine Surgery. These endeavors have lead to publications as well as over 100 lectures throughout North America, Europe and Asia.ĭr. He is also engaged in active research and education projects. His practice is dedicated to providing comprehensive operative and non-operative treatments for spinal ailments with a special interest in minimally invasive surgical techniques. He holds Board Certifications from the American Board of Spine Surgery, American Board of Orthopaedic Surgery and American Board of Independent Medical Examiners. He also founded and owns Prairie Surgicare, an AAAHC certified surgical facility. Kube II, MD, FACSS, FAAOS, CIME is a fellowship trained spine surgeon and Founder/Owner of Prairie Spine & Pain Institute, in Peoria, Illinois. It also demonstrates that CD18 is required for chemokine-induced leukocyte transendothelial migration, independent of its known role in mediating firm adhesion.Richard A. To our knowledge, this study is the first to show increased sensitivity to a CC chemokine in a model with preexisting inflammation, and altered leukocyte recruitment profiles in response to MCP-1. However, the CD18 antibody did block emigration. In adjuvant-immunized animals, leukocyte adhesion was reduced by antibodies against the α4-integrin but not by antibodies against CD18. In naive animals, an antibody against CD18 blocked leukocyte adhesion and emigration in response to MCP-1. Flow cytometry revealed novel expression of the CC chemokine receptors CCR1 and CCR2 on neutrophils from adjuvant-immunized animals. In vitro, MCP-1 was also able to induce chemotaxis of neutrophils isolated from adjuvant-immunized rats but not from naive rats. ![]() Surprisingly, histology revealed that neutrophils constituted the majority of leukocytes recruited in adjuvant-immunized animals. MCP-1 elicited increased leukocyte transendothelial migration in adjuvant-immunized rats compared with naive animals. Therefore, MCP-1 was superfused over the mesentery of naive rats or rats with chronic adjuvant-induced vasculitis. However, the function of this chemokine in models with preexisting inflammation is not known. Monocyte chemoattractant protein-1 (MCP-1) is a CC chemokine that stimulates monocyte recruitment when injected into tissues of healthy animals.
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